Sarcopenia trunkal obesity diabetes inflection point ProJR: Managing sarcopenia and visceral fat driven vascular outcomes in patients with or without diabetes.
Managing sarcopenia and visceral fat driven vascular outcomes in patients with diabetes
Problem statement/Background
"Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength, and quality) and vascular outcomes in T2DM remain poorly investigated.
Quoted from reference 1: https://cardiab.
Even while it's easy to qualitatively spot individuals with reduced limb muscle mass and trunkal fat it is important to establish that improving limb muscle mass and trunkal fat utilizing diet and exercise strategies would improve cardiovascular outcomes in patients with diabetes mellitus.
AIM:
To improve vascular outcomes in patients at risk of diabetes evidenced by their increased visceral fat and reduced muscle mass and strength.
OBJECTIVES:
To assess various clinical and investigational characteristic of patients with sarcopenia and diabetes in relation to their outcomes.
To analyse patient outcomes based on morbidity (physical, social 7 psychological limitations) & mortality.
PATIENTS AND METHODS:
PLACE OF STUDY: Department of general medicine
STUDY PERIOD: November 2022-October 2024
STUDY DESIGN: Non experimental (observational) qualitative Prospective Study
SAMPLE SIZE: 50 patients
INCLUSION CRITERIA:
Patients of any gender above or equal to 18yrs of age at the time of presentation.
Patients presenting with a combination of sarcopenia and increased visceral fat with or without diabetes mellitus.
EXCLUSION CRITERIA:
1.Patients below 18 yrs of age (minors)
2.Patients not capable of giving consent (mentally ill patients)
3.Patients not willing to participate in study (non-consenting patients)
PROFORMA (data to be captured)
Demographics
Anthropometric indicators of sarcopenia and increased visceral fat:
Mid arm circumference
Abdominal circumference
Functional indices:
Hand grip
Biceps power
On investigation:
FBS, PPBS, Hba1c
Chest X-ray -PA view
ECG
2D ECHO
CBP
Serum creatinine
Patient reported outcomes:
Daily exercise (in terms of routine activities)
Daily diet in the form of meal images captured before consumption
Blood sugar outcomes in terms of weekly FBS PPBS and Hba1c every three months
Vascular outcomes suggested by symptoms and signs of vascular events involving different organ systems supplied by macro and micro vessels such as cardiac, neurological, renal, ocular, cutaneous etc.
Links to a spectrum of detailed individual patient PaJR proforma data and outcomes over few years: 
MASTER CHART WITH LINKS TO PATIENTS E-LOG
Link To Master Chart:
PATIENT INFORMATION SHEET
English:
Telugu:
Template of this "patient information sheet" is borrowed from this website:
And modified accordingly to my thesis topic.
REFERENCES:
1) Murai, J., Nishizawa, H., Otsuka, A. et al. Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation. Cardiovasc Diabetol 17, 112 (2018). https://doi.org/10.1186/
Detailed 2021 batch tentative thesis titles here: http://medicinedepartment.
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