[26-06-2025 07:03] PPM 5: Moong chilla etc anything in cooked form is good but unfortunately sprouted moong is not good for vatta dosha.
[27-06-2025 07.09] PA: Morning black tea with puffed rice.
[27-06-2025 08.28] PA: Breakfast roti with curry.
[28-06-2025 09:04] PA: The patient can't understand what's happening. From last few days even today morning she felt very weak, even her vision turns dark. After doing little work. Even after a full meal like lunch and dinner she feels very weak and breathlessness. All the works which she has to do forcefully..if she closes her eye feels good.
[28-06-2025 09:20] PPM 5: Is this because of low BP @PPM1 Sir?
Would salt and lemon mixed with water (no sugar) help?
[28-06-2025 09:21] PA: Just now she had salt and lemon water.
[28-06-2025 09:27] PPM 1: Her recorded BP as shared and archived appears to be normal
Again the only way to get to the bottom of these symptoms is to analyse the events preceding and following them
[28-06-2025 10:11] PPM 5: Could this also be because of haemoglobin deficiency or thyroid imbalance?
[28-06-2025 10:14] PPM 1: From what I recall from memory if not her archived case report (@CR would it be possible to fish out her hemogram and thyroid function tests from there), she had a normal Hb and thyroid function test.
[28-06-2025 11.48] CR: 👆test reports of 28/12/24
[28-06-2025 12:04] PPM 5: TSH?
[28-06-2025 12:05] CR: Couldn't find. @PA do you have any Thyroid reports?
[28-06-2025 12:15] PA: Dated on 19/10/24
[28-06-2025 12:30] PA: Constant vomiting tendency
[28-06-2025 12:30] PA: No taste to eat anything. Slight pain in abdomen
[28-06-2025 12:30] PA: Whichever I am doing and eating have to do forcefully.
[28-06-2025 12:49] PPM 1: Please start the patient's hourly activities description from waking up yesterday till now specifically mentioning which hours the patient started feeling the symptoms and at which hours they continued
[28-06-2025 13:26] PA: Yesterday she ate prasad khichuri, that could be the reason for vomiting tendency.
[28-06-2025 13:37] PA: This morning she ate 4 Kheera slices, black plum and chole and potato mix
[28-06-2025 14:30] PPM 1: 👆 yesterday's?
[28-06-2025 14:58] PA: No. today snack time
[28-06-2025 15:01] PA: Woke up at 6.am
[28-06-2025 15:06] PA: Then freshen up and clean the room and bed feels very weak and vison turns dark. After that she checks her BP. Then lied down on the bed for some time.
[28-06-2025 15:16] PA: After that she gave lunch box to her daughter and had small quantity of rice and gram mixed chila. (At that time she felt very uneasy, and had little piece of chilla)
[28-06-2025 15:20] PA: After half an hour then she takes a glass of water with salt and lemon.
[28-06-2025 15:25] PA: Then she took bath and after that had severe nausea and vomiting. Then she had some relief.
[28-06-2025 15:26] PA: It continues for about 2-3hours.
[28-06-2025 15:31] PA: 11.15 am she had lunch but couldn't eat much. After that she takes metformin 500 half tab and relaxed for some time.
[28-06-2025 15:34] PA: Then she goes to her tailoring shop which is situated in front of the house.
[28-06-2025 15:36] PA: She has no taste
[28-06-2025 15:38] PA: Weakness is continuously there since morning.
[28-06-2025 16:48] PPM 1: Clinically she appeared euthyroid with a normal hemoglobin during her recent visit here. @PA when was her last visit here?
[28-06-2025 18:23] PA: She visited the last week of March this year. Mostly they reached 25th of March
[28-06-2025 18:25] PA: What is euthyroid? Can you tell me pl
[28-06-2025 18:43] PA: I think it may be right.If u noticed that in yesterday's lunch plate there were small pieces of paneer 2-3pic in veggies and all were homemade but after eating there were no complications. I think the dinner plate didn't suit.
[28-06-2025 18:45] PPM 5: @Meta AI what is euthyroid?
[28-06-2025 18:45] Meta AI: Euthyroid refers to a state of normal thyroid function. When your thyroid gland is working properly, producing the right amount of thyroid hormones, you're considered euthyroid. This balance is crucial for metabolism, energy, and overall health. If you've had thyroid issues or are experiencing symptoms, getting to a euthyroid state is usually the goal of treatment!
[28-06-2025 18:46] PPM 5: @Meta AI What are abnormal readings for thyroid? What parameter should be tested? What hormonal changes could be affecting thyroid?
[28-06-2025 18:46] Meta AI: Let's break it down:
Abnormal Readings:
1. TSH (Thyroid-Stimulating Hormone):
- High TSH (above 4.5-5 μU/mL): May indicate hypothyroidism (underactive thyroid).
- Low TSH (below 0.4-0.5 μU/mL): May indicate hyperthyroidism (overactive thyroid).
2. Free T4 (FT4):
- Low FT4 (below 0.8-1.2 ng/dL): May indicate hypothyroidism.
- High FT4 (above 1.7-1.8 ng/dL): May indicate hyperthyroidism.
3. Free T3 (FT3):
- Low FT3 (below 2.3-4.2 pg/mL): May indicate hypothyroidism.
- High FT3 (above 4.2-6.8 pg/mL): May indicate hyperthyroidism.
Parameters to Test:
1. TSH
2. Free T4 (FT4)
3. Free T3 (FT3)
4. Thyroid Antibodies (e.g., TPOAb, TgAb) to check for autoimmune thyroiditis
Hormonal Changes Affecting Thyroid:
1. Thyroid Hormones (T3 and T4): Imbalances can cause hypothyroidism or hyperthyroidism.
2. Thyroid-Stimulating Hormone (TSH): Produced by the pituitary gland, TSH regulates thyroid hormone production.
3. Thyrotropin-Releasing Hormone (TRH): Produced by the hypothalamus, TRH stimulates the pituitary gland to release TSH.
Other factors that can affect thyroid function include:
1. Iodine deficiency or excess
2. Certain medications (e.g., lithium, amiodarone)
3. Autoimmune disorders (e.g., Hashimoto's thyroiditis, Graves' disease)
4. Pregnancy or postpartum changes
5. Pituitary or hypothalamic dysfunction
Keep in mind that test results should be interpreted by a healthcare professional, considering individual factors and medical history.
[28-06-2025 20:26] PA: Does she need to test T3, T4, TSH and hemoglobin?
[28-06-2025 20:30] PPM 1: I have a feeling it will turn out to be normal but not much harm in testing once I guess
[28-06-2025 20:32] PA: Ok
[28-06-2025 20:33] PA: Day after tomorrow she will get done.
[29-06-2025 05:53] PA: Fasting blood sugar level is 106
[29-06-2025 06:51] PA: BP 122/77, PR 80. After 3 min standing BP is 87/60, PR 94
[29-06-2025 07:24] PPM 1: This is a very significant postural drop @PPM5 @PPM10 @CR @PPM2 @PPM3 @30F PA
Let's ask the patient to continue to monitor this also perhaps confirming this with another BP instrument and approach the local doctor in case she needs iv fluids.
@PA how is she feeling today? Does she have a lot of giddiness especially after standing from lying down?
[29-06-2025 07:26] PPM 1: @PPM5 as far as I can recall and @CR may know from her archived data this is probably the first time we are seeing this postural drop in this patient and as @PPM3 may LLM inform us that while this can be due to machine error, it generally commonly indicates hypovolemia and rarely dysautonomia.
[29-06-2025 07.31] PA: BP 127/85, PR 94, BP 84/59, PR 97
[29-06-2025 07:31] PPM 5: By any chance can it also be Addison's disease?
[29-06-2025 07:31] PA: As per Last week BP monitor
[29-06-2025 07:34] PPM 5: LLM output on ruling out these -
To rule out or confirm hypervolemia, dysautonomia, and Addison’s disease, you need to use a combination of:
Clinical signs and symptoms
Vital signs (especially blood pressure, heart rate)
Basic and targeted lab tests
Sometimes imaging or autonomic function tests
Here's a side-by-side approach to help differentiate and rule each one out:
---
🩸 1. Ruling Out Hypervolemia (Fluid Overload)
✅ Key Signs to Look For:
Swelling in legs, feet, face (edema)
Rapid weight gain (2–3 kg over a few days)
Shortness of breath, especially when lying down
High or normal BP
Jugular venous distension (JVD)
🧪 Tests:
Test What it shows
Chest X-ray Fluid in lungs (pulmonary edema)
BNP or NT-proBNP Elevated in heart failure (fluid overload)
Electrolytes, BUN/Creatinine Kidney function
ECG, Echocardiogram Underlying heart function
Urine output monitoring Low output in fluid overload with kidney failure
🚫 Hypervolemia is unlikely if:
No edema or weight gain
No crackles in lungs
Chest X-ray is clear
BNP is normal
No JVD
---⚡ 2. Ruling Out Dysautonomia
Key Signs to Look For:
Dizziness when standing
Heart rate jumps on standing (especially in POTS)
Fatigue, fainting, brain fog
GI issues, sweat changes
🧪 Tests:
Test What it shows
Orthostatic vitals Measure BP & HR lying, sitting, standing (after 3–10 min)
Tilt table test Definitive test for orthostatic hypotension or POTS
24-hr Holter/ECG HR variability, arrhythmias
QSART (sweat test) Tests autonomic nerve function
Valsalva test Measures autonomic reflexes
🚫 Dysautonomia is unlikely if:
BP and HR remain stable on position change
No dizziness or tachycardia with standing
Autonomic function tests are normal
---
🧬 3. Ruling Out Addison’s Disease (Primary Adrenal Insufficiency)
✅ Key Signs to Look For:
Extreme fatigue
Low BP (especially diastolic)
Darkened skin (esp. gums, scars)
Weight loss, nausea
Salt craving
Low blood sugar
High potassium, low sodium
🧪 Tests:
Test What it shows
8 AM Serum Cortisol Low (<3 µg/dL suggests Addison’s)
ACTH stimulation test (Synacthen test) No cortisol rise confirms Addison’s
Plasma ACTH High ACTH = primary (Addison’s); low = secondary cause
Electrolytes Low sodium, high potassium, low glucose
Renin and aldosterone High renin, low aldosterone in Addison’s
🚫 Addison’s is unlikely if:
Cortisol is normal or increases after ACTH stimulation
ACTH is not elevated
Electrolytes and blood sugar are stable
---
🧠 Summary Table:
Condition Key Signs First Tests Rule Out If...
Hypervolemia Edema, SOB, high BP BNP, Chest X-ray No fluid signs, normal imaging
Dysautonomia Dizziness on standing, HR jumps Orthostatic BP/HR, tilt table BP & HR stable on position change
Addison’s Fatigue, low BP, hyperpigmentation AM cortisol, ACTH stim Cortisol normal, no electrolyte changes
---
📌 If you are evaluating a real patient:
You can start with:
1. Orthostatic BP/HR check
2. AM cortisol + electrolytes
3. Chest X-ray + BNP if suspecting fluid overload
4. Refer for autonomic function testing if needed
Let me know the patient's age, history, and exact symptoms if you’d like a more focused diagnostic pathway.
[29-06-2025 07:41] PA: Please sir, don't suggest Iv fluids. Last Oct. 60 bottles of fluids were given. Even today she is terrified, whatever medicines or advice you give, she will follow but please don't say to iv again.
[29-06-2025 07:44] PA: Today is feeling better than Yesterday when she lays on the bed but after standing feeling weak and vision turns dark .. vomiting tendency is there.
[29-06-2025 07:47] PA: Today her schedule is very tight not possible to lie down on the bed all day.
[29-06-2025 07:56] PPM 5: @PPM1 Sir AI output
Prompt -
This patients vision turns dark if she stands up from a sleeping posture. Also has vomitting tendency.
AI output -
Thanks — that's a very important clinical detail. The fact that her vision turns dark when standing up from lying down, along with vomiting tendency, strongly points toward orthostatic hypotension, which may be due to:
---
Likely Causes Based on These Symptoms:
1. Addison’s Disease (Primary Adrenal Insufficiency) – HIGHLY SUSPECTED
Postural (orthostatic) hypotension
Fatigue, nausea, vomiting
Dark vision on standing = brain hypoperfusion
Possible hyperpigmentation
Low cortisol + low aldosterone = poor vascular tone, salt loss
2. Dysautonomia (e.g., Neurogenic orthostatic hypotension or POTS)
Especially if she also has GI symptoms and HR increase on standing
Nervous system unable to regulate BP correctly when changing position
3. Volume Depletion (hypovolemia) – less likely if BP is persistently low
Due to vomiting, diarrhea, poor intake, diuretics
But doesn’t fully explain persistent postural symptoms unless dehydration is severe
---
Step-by-Step Diagnostic Plan You Should Ask Her Doctor to Perform:
1. Orthostatic Vital Signs
Measure BP & HR:
Lying down (5 min)
Immediately on standing
After 3 min standing
Diagnostic if:
Systolic drops ≥20 mmHg or diastolic ≥10 mmHg
HR rise >30 bpm (suggests POTS)
Lightheadedness, vision darkening, nausea on standing
2. Basic Blood Tests
Test What It Detects
Serum Electrolytes (Na, K) Addison’s = Low Na, High K
8 AM Cortisol Low (<3 µg/dL) = suspicious
ACTH High with low cortisol = Addison’s
Glucose Often low in Addison’s
Renin & Aldosterone High renin, low aldosterone in Addison’s
3. ACTH (Synacthen) Stimulation Test
Confirms adrenal insufficiency if cortisol does not rise after stimulation
4. ECG / ECHO / Chest X-ray
To rule out cardiac cause or hidden fluid overload (if needed)
Optional Autonomic Tests (if cortisol is normal):
Tilt table test
Valsalva test
QSART (sweat test)
---
🧠 Working Hypothesis Based on What You've Shared:
> "Probable Addison’s disease or orthostatic hypotension due to dysautonomia, given postural symptoms, vomiting, and low diastolic BP."
---
🩹 What Can Help Temporarily (Until Tests Are Done):
Increase salt intake (unless contraindicated)
Drink oral rehydration or electrolyte-rich fluids
Slow posture changes (lie → sit → stand gradually)
Raise head of bed slightly during sleep
Avoid prolonged standing or heat
---
[29-06-2025 08:58] PA: She just completes her breakfast with upma and fruits then takes metformin 500 half tab
[29-06-2025 10.04] PA: BP 107/66, PR 85
[29-06-2025 10:07] PA: After having breakfast she took rest still now, then checked BP that is 107/66
[29-06-2025 10:09] PA: After 3 mints standing BP is 102/70
[29-06-2025 10:40] PPM 11: What medicines are she on apart from metformin?
[29-06-2025 10:41] PA: 2hours later sugar level is 153
[29-06-2025 10:45] PA: She takes metformin 500 half tab after breakfast, lunch and dinner.
[29-06-2025 10:45] PPM 11: Any other medicines?
[29-06-2025 10:46] PA: No sir
[29-06-2025 14:16] PPM 5: No darkness in vision after standing? When does that happen? Only in the morning when waking up?
[29-06-2025 14.35] PA: 126mg/dl
[29-06-2025 15:29] PPM 2: But again the heart rate is 'fixed' at 94 to 97 while the BP drops.
Certainly raises the case for Dysautonomia
[29-06-2025 15:30] PPM 2: What phenotype of Diabetes does she have you think sir? @Rakesh Biswas Sir
[29-06-2025 15:30] PPM 2: @PA has the patient been losing weight or lost weight before she was diagnosed with Diabetes?
[29-06-2025 15:57] PA: BP 122/81, PR 108Yes sir now she feels better even from yesterday takes lemon water with salt several times.
[29-06-2025 15:59] PA: She also feels that lemon water with salt and black tea enhances her energy when it feels weak.
[29-06-2025 16:02] PA: Most of the day she notices that either morning or evening feels weak, sweating etc.
[29-06-2025 16:08] PPM 1: Type 2 although monogenic is always a fallback possibility
She had a metabolic syn phenotype earlier which she worked upon and changed to what is her current DP.
@PA can the patient share the deidentified views of her previous abdomen and arms lateral view before she worked out and made significant changes to her body?
[29-06-2025 16:10] PA: No sir, It has been a weight loss since last sept. Before that she looked like round and chubby.
[29-06-2025 16:15] PPM 1: When was she first diagnosed to have diabetes?
[29-06-2025 16:17] PPM 1: Since last September the weight loss was because the patient was proactive about her health and while she needed glimiperide before that she's currently off glimiperide and with fair amount of sugar control.
[29-06-2025 16:33] PPM 1: Please share images of her at the time she developed diabetes 3 years back
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