28/12/23:
[04/01/24, 1:54:29 PM] PPM 3:
[04/01/24, 4:09:26 PM] PPM 1 : Creatinine 0.9
Deleting the previous image as patient identifiers are visible
[05/01/24, 10:40:17 AM] PPM 3: Breakfast
Dinner
[09/01/24, 8:28:00 AM] PPM 1: Weekly 10 readings of home BP in 24 hours?
Weekly home Fbs, ppbs after every meal (4 values, one fasting, 3 two hour post meal, assuming three meals)
[09/01/24, 9:31:59 AM] PPM 3: Ok sir
[09/01/24, 9:55:12 AM] PPM 3: Patient complaining of pins and needle sensations in her legs
[09/01/24, 11:21:56 AM] PPM 3: Image omitted
[09/01/24, 11:23:11 AM] PPM 1: 10 readings expected today spaced out at random intervals over 24 hours
[09/01/24, 11:25:42 AM] PPM 3: Ok sir
[09/01/24, 11:37:50 AM] PPM 3:
[09-01-2024 11.38] PPM 3: Post breakfast GRBS 398mg/dl
[09/01/24, 11:44:07 AM] PPM 1 : What tablet did she take before this?!! 🧐😳
[09/01/24, 11:48:00 AM] PPM 3: Sir she took Tab Glimi 1.5 mg + Tab Metformin 500 mg before breakfast
[09/01/24, 11:53:30 AM] PPM 1: She needs to increase the dose of Glimeperide to 2 mg asap from tomorrow
What about her fasting today?
[09/01/24, 12:00:30 PM] PPM 3: Ok sir. She’ll get it done tomorrow morning.
[09/01/24, 12:10:28 PM] PPM 1: Ask her to report all her two hour post meal sugars today
[09/01/24, 12:13:40 PM] PPM 3: Ok sir
[09/01/24, 12:22:33 PM] PPM 3: 157/99, PR 84
[09/01/2024 13.34] PPM 3: 139/90, 83
Dinner
[10/01/24, 11:33:38 AM] PPM 3:
[10/01/24, 11:35:37 AM] PPM 3: 145/108, 83
[10/01/24, 11:51:42 AM] PPM 3: FASTING GRBS: 264mg/dl
[10/01/24, 2:25:56 PM] PPM 1: Our hospital lab?
[10/01/24, 2:29:08 PM] PPM 3: Outside lab sir
[10/01/24, 2:31:05 PM] PPM 1: Was the method used hplc or latex?
What method does our lab use?
[10/01/24, 2:35:40 PM] PPM 3: Sir our lab uses latex method
[10/01/24, 2:37:42 PM] PPM 1: And their lab?
[10/01/24, 2:38:44 PM] PPM 1: What are the comparative effectiveness results reported in terms of sensitivity specificity of both?
Lunch
[10/01/24, 4:25:16 PM] PPM 3: Post lunch GRBS 356mg/dl
[10/01/24, 4:33:34 PM] PPM 1: The tablets in the image don't reduce pins and needle sensations
She needs to be put on Tablet Pregabalin 75 mg one hour before dinner regularly for that
[10/01/24, 4:54:46 PM] PPM 3:
Tab. Glimi 2.5 mg po/od before breakfast
Tab. Glimi 0.5mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast and after dinner
[10/01/24, 4:58:44 PM] PPM 1: Also after lunch
[10/01/24, 5:00:24 PM] PPM 3: Ok sir
[10/01/24, 8:13:06 PM] PPM 3: 268mg/dl
[10/01/24, 8:13:06 PM] PPM 3: Pre dinner GRBS
[10/01/24, 8:14:02 PM] PPM 1: Let her take Glimeperide 0.5mg
[10/01/24, 8:21:07 PM] PPM 3: Ok sir
[10/01/24, 8:52:14 PM] PPM 3: Dinner
[11/01/24, 8:44:13 AM] PPM 3: Fasting GRBS 242mg/dl
Breakfast:
[11-01-2024 13.35] PPM 3: BP 146/91, PR 89, Post breakfast GRBS: 365mg/dl, Pre lunch GRBS: 277mg/dl
Lunch:
Dinner:
[12/01/24, 7:48:36 AM] PPM 3: Fasting GRBS 285mg/dl
Breakfast:
[12-01-2024 13.45] PPM 3: Post breakfast GRBS: 234mg/dl, Pre-lunch GRBS: 313mg/dl
Lunch:
[12-01-2024 15.45] PPM 3: Post lunch GRBS: 340mg/dl
[12-01-2024 20.15] PPM 3: Pre dinner GRBS: 302mg/dl
Dinner:
[12-01-2024 22.15] PPM 3: Post dinner GRBS: 267mg/dl
[13/01/24, 9:19:34 AM] PPM 3: Fasting GRBS: 307mg/dl

Breakfast:
[13-01-2024 11.30] PPM 3: Post breakfast GRBS: 373mg/dl
[13-01-2024 14.00] PPM 3: Pre lunch GRBS: 273mg/dl
Lunch:
[14-01-2024 20.55] PPM 3: Pre dinner GRBS 300mg/dl
Tab. Glimi 3mg po/od before breakfast
Tab. Glimi 1.5mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
[14-01-2024 22.55] PPM 3: Post dinner GRBS: 354mg/dl
[15/01/24, 12:08:51 AM] PPM 3:
[15-01-2024 15.25] PPM 3: Post lunch GRBS: 229mg/dl
Lunch:
[16-01-2024 11.51] PPM 3: Fasting GRBS 280mg/dl
Breakfast:
[16-01-2025 20.13] PPM 3: Pre dinner GRBS: 267mg/dl
[17/01/24, 1:11:01 PM] PPM 3: Pre lunch GRBS 261mg/dl
Post lunch GRBS: 281/g/dl
[18/01/24, 7:51:19 PM] PPM 1: Try to explain to her that the two hour post meal can tell us best about the effect of the drug rather than just a pre meal sugar as the timing of the pre meal is likely to change everytime with whenever the patient wants to have the meal whereas two hour post meal will always be two hour post meal
[18/01/24, 8:06:11 PM] PPM 3: Ok Sir
[18/01/24, 8:06:21 PM] PPM 3:
Tab. Glimi 3.5 mg po/od before breakfast
Tab. Glimi 2.5mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Pre dinner GRBS: 224mg/dl
Dinner:
Post Dinner GRBS: 288mg/dl
[19/01/24, 8:26:39 AM] PPM 3:
Tab. Glimi 3.5 mg po/od before breakfast
Tab. Glimi 2.5mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Fasting GRBS: 260mg/dl
Breakfast:
Pre lunch GRBS: 225mg/dl
Lunch:
Post lunch GRBS: 228mg/dl
Pre dinner GRBS: 287mg/dl
Dinner:
[20/01/24, 8:51:09 AM] PPM 3: Fasting GRBS: 268mg/dl
Tab. Glimi 3.5 mg po/od before breakfast
Tab. Glimi 2.5mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Breakfast:
Post Breakfast GRBS: 271mg/dl
Pre lunch GRBS: 205mg/dl
Lunch:
Post Lunch GRBS: 215mg/dl
Dinner:
Post dinner GRBS: 247mg/dl
[20/01/24, 11:43:40 PM] PPM 1: 👍
[21/01/24, 1:10:04 PM] PPM 3: Fasting GRBS: 241mg/dl
Breakfast:
Lunch:
Post Lunch GRBS: 192mg/dl
Dinner:
[22-01-2024 09.21] PPM 3: Fasting GRBS: 260mg/dl
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3 mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Lunch:
Post lunch GRBS: 188mg/dl
[23/01/24, 11:11:26 AM] PPM 3: 212mg/dl
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3 mg po/od after dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Breakfast:
[24/01/24, 12:39:36 PM] PPM 3:
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3 mg po/od before dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Breakfast:
Lunch:
Post Lunch GRBS: 251mg/dl
25/01/24:
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3 mg po/od before dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Fasting GRBS: 227mg/dl
Breakfast:
Lunch:
Post Lunch GRBS: 306mg/dl
Dinner:
Post dinner GRBS: 201mg/dl
[26/01/24, 3:01:31 AM] PPM 3: Fasting GRBS 228mg/dl
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3 mg po/od before dinner
Tab. Pregabalin 75mg po/od 1hr before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Breakfast:
Lunch:
Post lunch GRBS: 298mg/dl
Dinner:
Post Dinner GRBS: 278mg/dl
[27/01/24, 12:08:26 AM] PPM 3: Fasting GRBS: 242mg/dl
Breakfast:
Dinner:
Post dinner GRBS: 193mg/dl
[28/01/24, 11:23:33 AM] PPM 3: Fasting GRBS 177mg/dl
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3.5 mg po/od before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
Lunch:
Post lunch GRBS: 228mg/dl
Dinner:
Post dinner GRBS: 184mg/dl
[29/01/24, 2:51:48 AM] PPM 3:
Tab. Glimi 4 mg po/od before breakfast
Tab. Glimi 3.5 mg po/od before dinner
Tab. Metformin 500mg po/bd after breakfast, after lunch and after dinner
[29/01/24, 8:26:43 AM] PPM 1 : How did it come down to ideal levels of control all of a sudden with current maximal doses of Glimeperide 4 mg before breakfast and 3.5mg before dinner?
How much metformin is she taking and when?
[29/01/24, 1:07:21 PM] PPM 3: Sir might be she is restricting her diet may be that’s why her post meal GRBS is coming down.
[29/01/24, 1:10:12 PM] PPM 3: Sir also here she only had a glass of milk in the dinner hence the post meal GRBS value 193 and also the next day fasting GRBS was 177
[30-01-2024 07.26] PPM 3: Fasting GRBS: 241mg/dl
Breakfast:
Lunch:
Post lunch GRBS: 266mg/dl
Dinner:
Post dinner GRBS: 158mg/dl
Learning point:
P(Population):
A total of 154 samples from patients with diabetes type 2 with HbA1c concentration covering the whole clinical range were analyzed by four commercially methods
I (Intervention):
A total of 154 samples from diabetic patients with HbA1c concentration covering the whole clinical range, were obtained through venipuncture into sterile tubes containing the EDTA K2 and tested with 4 assays ( 1.Ion exchange HPLC method , 2.Immunoassay , 3.Boronate affinity chromatography , 4.Ion exchange chromatography )within 2 days
C ( Comparison):
HbA1c measurement was performed concurrently in all cases by four commercially available assays:
1.D-10 Hb A1c (Bio-Rad Laboratories, Hercules, CA), Ion exchange HPLC method
2.Cobas Integra 400 (Roche Diagnostics, Mannheim, Germany), Immunoassay
3.NycoCard Reader II, (Axis-Shield, Oslo, Norway), Boronate affinity chromatography
4.DS5, (Drew Scientific, Le Rheu, France), Ion exchange chromatography
O ( Outcome) :
Total precision (in term of CV%) were less than 1.6 %, 1.0 %, 3.1 % and 3.3 % for D10, cobas integra 400, Nycocard reader II and DS5 respectively. The mean ± SD value of HbA1c was significantly higher when measured by D10 (7.59 % ± 1.43 %) than when estimated with the Nycocard reader II (6.87 % ± 1.17 %, r: 0.937, P < 0.05) and DS5 (6.69 ± 1.47 %, r: 0945, P < 0.05) and almost same compared to cobas integra 400 (7.66 ± 1.45, r: 0.944, P: 0.06).

49F DM WITH UNCONTROLLED SUGARS
APRIL 19, 2024
A 49 years old Female who is a house wife by occupation came with C/O
Fever since 15 days
Patient was apparently asymptomatic 9 years back then she started having bleeding per vagina for which she went to hospital & Diagnosed to have ? Fibroid uterus for which she went to a private hospital in hyderabad for hysterectomy as advised in local hospital. Then she had high sugars for the first time (Around 450mg/dl).So she was admitted in the hospital & hysterectomy was done after controlling the sugars with Insulin. Then she was discharged with Tab. GLIME M1 PO BD & continued the tablet for 3 years along with diabetic diet. Then she came to our OP for Follow then she was prescribed with Tab. GLIME M2 PO BD which she used for 2 years. Then she came to our OP for Follow up then she was escalated to Tab. GLIME M3 PO BD
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